ncRNA name | MIAT |
ncRNA Category | lncRNA |
ID | 440823 |
Ensembl | ENSG00000225783 |
Synonyms | C22orf35, FLJ25967, LINC00066, NCRNA00066, Rncr2, gomafu, lncRNA-MIAT |
Disease name | age-related cataract |
Species | Homo sapiens |
Tissues/Cell_line | lens, aqueous humor; human lens epithelial cell line SRA01/04 |
Methods | microarray, qRT-PCR, siRNA transfection, Calcein‐AM and PI staining, immunofluoresence, MTT assay |
Expression pattern | up-regulated |
Functional description | MIAT knockdown could affect the proliferation, apoptosis and migration of Human lens epithelial cells (HLECs) upon oxidative stress. MIAT knockdown could repress tumour necrosis factor-α-induced abnormal proliferation and migration of HLECs, suggesting a potential role of MIAT in PCO-related pathological process. Moreover, we found that MIAT acted as a ceRNA, and formed a feedback loop with Akt and miR-150-5p to regulate HLEC function. |
PubMed ID | 26818536 |
Year | 2016 |
Title | Role of long non-coding RNA MIAT in proliferation, apoptosis and migration of lens epithelial cells: a clinical and in vitro study. |
Drug-related ncRNA | NO |
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